Allantoin: Skin Protectant

Allantoin, a naturally occurring compound found in various plants, has gained recognition for its exceptional skin-soothing properties. When used topically, allantoin is a potent skin protectant, offering many benefits that contribute to more resilient skin. 

Research studies have been conducted to study the anti-inflammatory properties of allantoin. The inflammatory response is an important step of the wound healing process as it prepares the wound's environment for repairing. However, this stage should not be prolonged because an excessive inflammatory response can delay wound healing. 

Results suggest that allantoin modulates the inflammatory response by inhibiting the chemotaxis of inflammatory cells in the site of the wound, thus preventing the release of reactive species responsible for oxidative stress and tissue damage. On the other hand, well-formed collagen fibers observed in the group treated with allantoin support its effectiveness in fibroblast proliferation and synthesis of extracellular matrix during wound healing (Araújo, 2010). 

Allantoin also has hygroscopic properties, meaning it can attract and retain water molecules. When applied to the skin, allantoin helps draw moisture from the environment and bind it to the skin, promoting hydration. Allantoin assists in strengthening the skin's natural barrier function as well. A healthy skin barrier helps lock in moisture and prevent excessive water loss from the skin (Vanessa, 2022). 

Allantoin’s inclusion in skincare products is rooted in its ability to moisturize, promote wound healing, and provide anti-inflammatory effects. The ingredient’s protective properties contribute to its widespread use, making it suitable for various skin types. 


Araújo, L. U., Grabe-Guimarães, A., Mosqueira, V. C., Carneiro, C. M., & Silva-Barcellos, N. M. (2010). Profile of wound healing process induced by allantoin. Acta cirurgica brasileira, 25(5), 460–466.  

Vanessa, V.V.; Wan Ahmad Kammal, W.S.L.; Lai, Z.W.; How, K.N. A Review of Moisturizing Additives for Atopic Dermatitis. Cosmetics 2022, 9, 75. cosmetics9040075